RESPONSIBLE AMINO ACID RESIDUE PREDICTION METHOD AND RESPONSIBLE AMINO ACID RESIDUE PREDICTION PROGRAM

摘要

PPROBLEM TO BE SOLVED: To provide a responsible amino acid residue prediction method that can presume a biological active part by analyzing variation information on a DNA sequence and an amino acid sequence using a quantitative theory even with a small number of samples. PSOLUTION: Out of matrixes having the difference between the amino acid sequence of a plurality of strains of protein and the amino acid sequence of a reference strain of protein, as elements, the matrix consisting of all the columns each comprising at least one element showing the difference is set as a mother matrix. The maximum independent matrix having a prescribed column as a first column is computed from the mother matrix. a partial correlation coefficient of the MIC value of antibacterial drug and the maximum independent matrix is computed, and the computation of the partial correlation coefficient of the MIC value and the maximum independent matrix with a column different from the first column of the maximum independent matrix, as a first column is repeated the prescribed number of times. On each column of the mother matrix, the value obtained by dividing the sum of the product of the number of columns of the maximum independent matrix and the partial correlation coefficient, by the sum of the number of columns is computed as an expected value. PCOPYRIGHT: (C)2003,JPO