Methods and therapeutic compositions for utilization of adenosine 5'-triphosphate (ATP) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

摘要

The invention discloses methods for the utilization of adenosine 5-triphosphate (ATP) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The administration of ATP results in several therapeutic activities, which by acting in consort provide the methods for treatment of ALI and ARDS. These therapeutic activities are 1. The utility of ATP as a preferential pulmonary vasodilator, 2. The utility of the catabolic product of ATP, adenosine, as an anti-inflammatory agent, 3. The anti-thrombotic, pro-fibrinolytic activities of ATP and adenosine, and 4. The utility of ATP in improving organ and muscle function in advanced disease patients. Therapeutic compositions and procedures for treating ALI and ARDS by administration of ATP are provided.