首页>
外国专利>
Use of gene product of adenovirus early region 4 ORF-6 to inhibit repair of double-strand breaks in DNA
Use of gene product of adenovirus early region 4 ORF-6 to inhibit repair of double-strand breaks in DNA
展开▼
机译:腺病毒4区早期ORF-6基因产物在抑制DNA双链断裂修复中的应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides a modified adenovirus comprising genomic adenoviral DNA which has been modified so that (i) the only gene product of the early region (E4) that is expressed is open reading frame 6 (ORF-6), (ii) neither the gene product of the E1A region nor the gene product of the E1B region is expressed, and (iii) no other early or late gene products are expressed. The present invention also provides methods of inhibiting repair of breaks in double-stranded DNA in a cell, preventing concatamerization of linear wild-type adenoviral DNA, inhibiting V(D)J recombination of nucleic acid sequences encoding immunoglobulins, preventing apoptosis, and preventing and treating cancer.
展开▼