Boswellin compositions enhanced with 3-beta-acetyl-11-keto-beta-boswellic acid ('AKBA') industrial manufacture and uses

摘要

The biological activity of naturally occurring boswellic acids in specific plant extracts is enhanced by their peracetylation, preferably followed by silica gel treatment, or by peracetylation and mild oxidation to increase the ratio of 3--acetyl-11-keto--boswellic acid to -boswellic acid, 3--acetyl--boswellic acid and 11-keto--boswellic acid. The enriched compositions compared to the commercial extracts have enhanced biological activity toward a variety of proliferative and/or inflammatory afflictions in mammalian hosts and demonstrate synergism with other phytochemicals.