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Methods and compositions for the stimulation of human immunodeficiency virus-specific cytotoxic T lymphocytes employing autologous antigen-peripheral blood mononuclear cells
Methods and compositions for the stimulation of human immunodeficiency virus-specific cytotoxic T lymphocytes employing autologous antigen-peripheral blood mononuclear cells
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机译:使用自体抗原-外周血单核细胞刺激人免疫缺陷病毒特异性细胞毒性T淋巴细胞的方法和组合物
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摘要
A novel method of immunization, which can be used either prophylactically or therapeutically, is described. The method comprises coating of antigen presenting cells with a peptide and administering the peptide-coated cells to a mammalian subject to provoke an immune response. Useful peptides include peptides derived from viral or bacterial antigens or mutant oncogene or tumor suppressor gene products. Immunogens, constituted by the peptide-coated cells, are also described.
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