Association of the muscarinic cholinergic 2 receptor (CHRM2) gene with major depression in women

摘要

The present invention relates to the observation that women having an A→T 1890 polymorphism in the 3′ UTR of the cholinergic muscarinic receptor 2 (CHRM2) gene have an increased risk for developing major depression. The present invention provides diagnostic, screening and therapeutic methods based on that observation.