Virus-free vesicles for delivery of functional membrane bound proteins

摘要

The present invention is directed to methods for producing virus-free vesicles containing functional membrane proteins, and uses thereof. Preferably the virus-free vesicles contain a type II transmembrane protein which is a member of the TNF superfamily. The vesicles maintain the protein in its native conformation, thus eliminating the problems related to the solubility of these proteins when produced without presence of membrane component.