22s-hydroxycholesta-8, 14-diene derivatives with meiosis regulating activity

摘要

The invention relates to 22S hydroxycholesta-8, 14-diene derivatives having general formula (I) wherein R₁ is OR, OSO₃H or NOR; with R being H, (C_1-6)alkyl or (C_1-6)acyl; each of R₂ and R₃ is independently hydrogen or (C_1-6)alkyl; R₄ is hydrogen, (C_1-6)alkyl or (C_1-6)acyl; R₅ is hydrogen; or R₅ designates, together with R₆, an additional bond between the carbon atoms at which R₅ and R₆ are placed; R₆ is hydrogen, hydroxy or halogen, or R₆ designates, together with R₅, an additional bond between the carbon atoms at which R₆ and R₅ are placed; each or R₇ and R₈ is independently hydrogen or (C_1-4)alkyl, optionally substituted with OH, (C_1-4)alkoxy, or halogen; or a pharmaceutically acceptable salt thereof. The compounds of the invention have meiosis activating activity and can be used for the control of fertility.