Method for determining the population of origin of an individual based on multi locus genotypes

摘要

A method to determine the population of origin of an individual, which includes: (a) identify a set of candidate populations of origin,Where each candidate population is characterized by frequencies of genotypes and frequencies of alleles at one or more loci markers; (b) to determine the genotype of the population of the prior probability for each individual and population of origin candidate using the knowledge referred to the INDI Individual available before determining the genotype of the individual; (c) to determine the genotype of the individualDuo to identify alleles at one or more loci markers identified in STEP (a) to identify the genotype of the individual; (d) based on the identified genotype of the individual.Sequentially to determine the probability of the genotype of the population for each candidate population of origin under the null hypothesis that the individual is originated from the population (e) combine the prior probability of genotype of the population from step (b) and the probability of the genotype of the P Oblation of Step (d) to obtain the posterior probability of the population for each Genotype.Poblaciom candidate origin; (f) to identify the most likely origin Population, where the population has the highest probability of subsequent genotype among the set of candidate Populations; and (g) to assign the individual to the population identified in STEP (f).