Pharmaceutical composition, pharmaceutical kit with one or more containers, methods for protecting a mammal from a pathology resulting from excitable tissue injury, for enhancing the function of normal or abnormal excitable tissue in a mammal, and for facilitating transcitosis of a molecule through an endothelial cell barrier in a mammal, and composition for transporting a molecule via transcinosis through an endothelial cell barrier

摘要

"PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL KIT WITH ONE OR MORE CONTAINERS, METHODS FOR PROTECTION OF A MAMMER OF A TISSUE PATHOLOGY FOR THE INTENSIFICATION OF THE FUNCTION OF AN EXCELLENT FABRIC FOR THE EXCELLENT NORMAL FABRIC OF A MOLECULATE THROUGH AN ENDOMELIAL CELL BARRIER IN A MAMMER AND COMPOSITION FOR TRANSPORTING A TRANSCINOSIS MOLECULATE THROUGH AN ENDENTIAL CELL BARRIER. " Methods and compositions for protecting or enhancing excitable tissue function in mammals are provided by systemic administration of an erythropoietin receptor activity modulator such as erythropoietin, which signals via an EPO-activated receptor to modulate the function of excitable tissue. Excitable tissues include central nerve tissues such as the brain, peripheral nerve tissues, retina, and cardiac tissue. Protection of excitable tissues provides treatment for hypoxia, attack disorders, neurodegenerative diseases, hypoglycemia, and neurotoxin poisoning. Function enhancement is useful for learning and memory. The invention also relates to compositions and methods for facilitating the transport of molecules across endothelial cell intimate junction barriers, such as the blood-brain barrier, by associating molecules with an erythropoietin receptor activity modulator such as a erythropoietin.