Use of 5- (2-pyrazinyl) -4-methyl-1-2-dithiol-3-thione (oltipraz) as a medicine, pharmaceutical composition for the prevention and treatment of hepatic fibrosis progression, use of 5- (2- pyrazinyl) -4-methyl-1,2-dithiol-3-thione and method for the prevention and treatment of fibrosis progression and liver cirrhosis

摘要

"USE OF 5- (2-PIRAZINYL) -4-METHYL-1,2-DITIOL-3-THIONA (OLTIPRAZ) AS A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF HEPATIC FIBROSIS PROGRESSION, USE OF 5- (2 -4-METHYL-1,2-DITIOL-3-THION AND METHOD FOR THE PREVENTION AND TREATMENT OF PROGRESSION OF FIBROSIS AND HEPATIC CIRROSIS ". The present invention provides a prophylactic and therapeutic use of 5- (2-pyrazinyl) -4-methyl-1,2-dithiol-3-thione (oltipraz) as an antifibrotic and anticyrrotic agent in the liver and a pharmaceutical composition containing oltipraz for treatment and prevention of fibrosis and liver cirrhosis. The oltipraz of the invention may be used as a medicament optionally with other drugs for the treatment and prevention of fibrosis and cirrhosis and has a relatively low dose inhibitory effect of hepatic fibrosis. Formulations using an optimum dose of oltipraz which is provided by the invention have a surprisingly good effect on the treatment and prevention of fibrosis and liver cirrhosis and are safe drugs that have low toxicity on the human organism.