Pharmaceutical product and daily pharmaceutical dose for administration to a patient, dose regimen providing an anti-androgenic effect and an antiestrogenic effect on a patient, use of a compound and tamoxifen or a pharmaceutically acceptable salt or solvate thereof, and, method for providing an anti-androgenic effect in a patient

摘要

"PHARMACEUTICAL PRODUCT AND DAILY PHARMACEUTICAL DOSE FOR PATIENT ADMINISTRATION, DOSE SCHEME TO PROVIDE ANTI-ANDROGENIC EFFECT AND ANTI-ESTROGENIC EFFECT IN A PATIENT, USE OF A COMPOUND AND TAMOXIFENOUS, AND A DOMATISE SOLOUS AND METHOD TO PROVIDE ANTI-ANDROGEN EFFECT ON A PATIENT. " The present invention relates to a daily dose or pharmaceutical dose regimen comprising 4'-cyano- 244 ', 244', 244 '-trifluoro-3- (4-fluorophenyl sulfonyl) -2-hydroxy-2-methylpropion-m-toluidide (compound I) and tamoxifen. The product comprises compound I and tamoxifen in a ratio of 25 to 350: 0.5 to 100 respectively. The invention also relates to a method of providing an anti-androgenic effect and an anti-estrogenic effect in a patient, wherein the antiestrogenic effects are provided substantially without causing an additional increase in circulating androgen levels.