首页> 外国专利> Substituted amine, protected compound, methods for treating a patient having or preventing a patient from contracting a disease or condition, inhibiting beta-secretase activity, inhibiting cleavage of amyloid precursor protein (app), inhibiting Production of the beta amyloid peptide (a beta) in a cell, to inhibit beta0amyloid plaque production in an animal, and to treat or prevent a disease comprising beta-amyloid deposits in the brain, composition method for producing a beta-secretase complex , assembly, and use of substituted amine

Substituted amine, protected compound, methods for treating a patient having or preventing a patient from contracting a disease or condition, inhibiting beta-secretase activity, inhibiting cleavage of amyloid precursor protein (app), inhibiting Production of the beta amyloid peptide (a beta) in a cell, to inhibit beta0amyloid plaque production in an animal, and to treat or prevent a disease comprising beta-amyloid deposits in the brain, composition method for producing a beta-secretase complex , assembly, and use of substituted amine

机译:取代的胺,受保护的化合物,用于治疗患有或预防患有疾病或病症的患者,抑制β-分泌酶活性,抑制淀粉样前体蛋白(app)裂解,抑制β淀粉样肽(β)产生的方法在细胞中,抑制动物中β-淀粉样蛋白斑的产生,以及治疗或预防脑中包含β-淀粉样蛋白沉积物的疾病,β-分泌酶复合物的合成方法,组装和使用取代胺的方法

摘要

"METHOD REPLACED, PROTECTED COMPOUND, METHODS TO TREAT A PATIENT WHO HAS OR TO PREVENT A PATIENT AGAINST A DISEASE OR CONDITION, TO INHIBIT THE ACTIVITY OF THE BETA SECRETASE, TO INHIBIT THE CLIVING OF THE PRECURSORA APPARATOR (AMEL), BETA AMYLOID PEPTIDE PRODUCTION (BETA) IN A CELL, TO INHIBIT BETA AMYLOID PLATE PRODUCTION IN AN ANIMAL AND TO TREAT OR PREVENT UNDERSTANDING BETA AMYLOID DEPOSITS, COMPOX COMPOUND COMPOX COMPOUND BETA SECRETASE, ASSEMBLY, AND USE OF A REPLACED AMINE ". The present invention are substituted amines of formula (XV): useful in the treatment of Alzheimer's disease and other similar diseases.
机译:“用替代方法,受保护的化合物来治疗患有或预防疾病或病症的患者的方法,以抑制β-淀粉酶的活性,以防止β-淀粉样蛋白前体涂药器(AMEL)的产生(BETA),以禁止在动物中生产β淀粉样板,并治疗或预防可理解的β淀粉样沉积物,COMPOX COMPOUND COMPOX复合BETA的分泌,组装和使用替代胺。本发明是式(XV)的取代胺:可用于治疗阿尔茨海默氏病和其他类似疾病。

著录项

  • 公开/公告号BR0111980A

    专利类型

  • 公开/公告日2003-05-06

    原文格式PDF

  • 申请/专利权人 ELAN PHARMACEUTICALS INC.;

    申请/专利号BR20010111980

  • 发明设计人 LAWRENCE Y. FANG;VARGHESE JOHN;

    申请日2001-06-29

  • 分类号C07C215/00;

  • 国家 BR

  • 入库时间 2022-08-22 00:03:49

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