Acid derivatives (compounds 1 - 5 -, 6 - or 7 - 1H indole - 3 - il) oxo acetic, their pharmaceutically acceptable salts or esters,Inhibitors of plasminogen activator inhibitor 1 (pai-1), Pharmaceutical composition containing them, and their use for the treatment of Thrombosis or fibrinolytic damage.

摘要

The present Invention provides compounds of formula:Where R1, R2, R3, R4 and x are defined in the statement of claim,Or a pharmaceutically acceptable Salt or Ester of the same, as well as methods for using such compounds as inhibitors of plasminogen activator inhibitor 1 (pai-1),As well as the therapeutic compositions to treat conditions that result from fibrinolytic Disorders such as deep vein Thrombosis and Coronary Heart Disease.And pulmonary fibrosis.