CRYSTALLINE EFAVIRENZ PHARMACEUTICAL COMPOSITIONS CONTAINING IT AS ACTIVE INGREDIENT, AND USE OF EFAVIRENZ FOR MAKING MEDICAMENT AVAILABLE FOR INHIBITIONS OF REVERSE TRANSCRIPTASE AND FOR TREATING HIV INFECTION

摘要

The potent reverse transcriptase inhibitor Efavirenz is produced in crystalline form. Crystalline Efavirenz exists in several physical forms which are designated Forms 1, 2, 3, 4 and 5 and are characterized by x-ray powder diffraction and differential scanning calorimetry. Pharmaceutical compositions and methods are useful for the treatment of the human immunodeficiency virus (HIV).