A process for the preparation of a novel fibrinolytic peptide from venom of snake indian king cobra (ophiophagus hannah) useful for pharmacological purposes.

摘要

A novel fibrinolytic peptide which produces non clotted blood in whole animal and develops halos in fibrin plates has been prepared from venom of snake Indian king cobra ( Ophiophagus hannah ). The said peptide having a molecular weight of 610 daltons and amino acid sequence asparate - glutamate glycin - alanine- leucine, prepared by chromatographic method and purified by high performance liquid chromatography, reveals strong defibrinogenating activity, fibrinolytic activity, fibrinogenolytic activity and devoid of phospholipase activity, haemorrhagic activity, haemolytic activity showing its potential use for pharmacological purposes.