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Transdermal drug delivery system containing the skin penetration enhancers crotamiton or diethyltoluamide
Transdermal drug delivery system containing the skin penetration enhancers crotamiton or diethyltoluamide
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机译:包含皮肤渗透促进剂克罗米通或二乙基甲苯胺的透皮给药系统
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摘要
A method of preparing a transdermal drug delivery system comprises: a) dissolving a pharmaceutically active substance in a solvent comprising one or more skin penetration enhancers to form a solution of active substance in the skin penetration enhancers at a concentration less than saturation; b) mixing the resultant solution with an adhesive in the form of an aqueous solution or dispersion; c) forming the mixture obtained in step b) into a film on a release liner or backing sheet and d) drying the film at a temperature less than the boiling point of the skin penetration enhancer or enhancers used as solvents in the dissolution step a). The skin penetration enhancer can be crotamiton or diethyltoluamide.
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