NEW ANALOGS OF CAMPTOTECHINE, PREPARATION PROCEDURE, ITS APPLICATION AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

摘要

THE INVENTION CONCERNS AN ANALOG OF THE CHARACTERIZED CAMPTOTECHINE WHY THE LACTONE HYDROXY OF THE CAMPTOTECHINE IS A BE} - LACTONE HYDROXY OR THE BE} - CORRESPONDING HYDROXIACIDE, WHICH DETERMINES THE OPENING OF THE LACTONE SUCH, OR A BEHIND - HYDROXIACIDE, OR A PHARMACOLOGICALLY ACCEPTABLE SALT OF THESE LAST COMPOUNDS, AND IN PARTICULAR COMPOUNDS OF GENERAL FORMULA (I) AND (II). THE INVENTION ALSO REFERS TO THE METHODS OF PREPARATION OF FORMULA (I) OR (II) COMPOUNDS, THE PHARMACOLOGICAL COMPOSITIONS CONTAINING THEM AND THEIR USE, IN PARTICULAR AS INHIBITORS OF THE TOPOISOMERASE AND ANTITUMOR.