SYNTHESIS OF HOMOCHIRAL 2-HYDROXY ACIDS

摘要

A process for the production of a homochiral 2-hydroxy carboxylic acid or salt thereof corresponding to general formula(I), wherein R represents one of formulae (II), (III), (IV), (V), wherein R' represents straight- or branched-chain alkyl or phenyloptionally para-substituted with methyl, methoxy, nitro or amino; and R" represents hydrogen, halogen or phenyl optionallypara-substituted with methyl, methoxy, nitro or amino; and M represents hydrogen or a salt-forming moiety; characterised in that itcomprises reducing a corresponding 2-keto carboxylic acid or salt thereof using a (R)- or (S)-2-oxo carboxylic acid dehydrogenase,inter alia, is disclosed.