A method for treating allergic disease and asthma by recombinant adenovirus-and adeno-associated virus-mediated ifn-gamma gene

摘要

The subject invention concerns an effective therapy for asthma, including allergic disease, using cytokine gene expression therapy. The subject invention further pertains to the use of adenovirus-mediated IFN-Ϝ (Ad-IFN-Ϝ) gene transfer to prevent or treat allergic disease and asthma, including associated conditions such as allergen-induced airway inflammation and airway hyperresponsiveness. The subject invention includes a method for effectively attenuating allergen-induced airway inflammation and airway hyperresponsiveness by administering to the respiratory tract Ad-IFN-Ϝ, to affect IL-12 and STAT-4 levels. The subject invention also provides compositions for gene therapy for asthma by the transfer of IFN-Ϝ