An RNA-binding protein Musashi 2 having an amino acid sequence represented by SEQ ID NO:1 or 2 or an amino acid sequence derived therefrom by substitution, deletion, addition or insertion of one or more amino acids; and its gene. The Msi2 protein and the Msi2 gene are useful as reagents for maintaining and growing nerve precursor cells/central nerve system stem cells. Also, they are useful as reagents for forming and/or maintaining PV-containing GABA-agonistic nerve cell subpopulations. Moreover, they are useful as remedies for various nerve system diseases.
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机译:RNA结合蛋白Musashi 2,其具有由SEQ ID NO:1或2表示的氨基酸序列或通过取代,缺失,添加或插入一个或多个氨基酸而从其衍生的氨基酸序列;及其基因。 Msi2蛋白和Msi2基因可用作维持和生长神经前体细胞/中枢神经系统干细胞的试剂。而且,它们可用作形成和/或维持含PV的GABA-激动神经细胞亚群的试剂。此外,它们可用作各种神经系统疾病的药物。
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