The present disclosure relates to a ligating instrument and end effector assemblies for use in laparoscopic tubal ligation procedures. The ligating instrument includes an integral grasping assembly and an integral end effector actuator and is configured to perform a ligating procedure by operation of a single hand of a user. The ligating instrument includes an integral grasper assembly for grasping a tubular tissue section and removable end effector or suture deployment mechanism for holding open a suture to be positioned about the tubular section. The grasper is configured to draw the tubular section into the open loop of suture material and cinch the suture material about the tubular tissue section. A rotator knob may be provided to orient grasper members associated with the grasper assembly relative to the tissue section. An alternative end effector is provided to removably mount on the distal end of the ligating instrument and to cut that part of the tubular tissue section which needs to be removed after the tubular tissue section has been ligated. A relatively soft over mold section may be provided to at least partially enclose the handle of the ligating instrument in order to provide comfort and facilitate a rsurer grip of the instrument.
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