A novel prenylated flavonoid-type compound showing antiinflammatory activity purified from Broussonetia papyrifera and extracts containing the said compound as a major component a method for preparing them and pharmaceutical compositions containing them

摘要

The present invention relates to a novel prenylated flavonoid compound and a coconut oil extract containing the same as a main component thereof, a process for producing the same, and a pharmaceutical composition containing the same. More particularly, the present invention relates to a method for producing a prenylated flavonoid compound of Broussonetia papyrifera, A novel plenylated flavonoid compound represented by the following formula (1), which is excellent in antiinflammatory effect, which is separated from muscle, by methanol and acetate extraction and chromatography, and a cocoa tree extract containing it as a main component; A salt thereof, a process for producing the compound and an extract thereof, and a pharmaceutical composition for treating an inflammatory disease comprising the same as an active ingredient. The novel plenylated flavonoid compound of the present invention and the extract of Cucurbitaceae containing it as a main component inhibits or inhibits the activity of enzymes involved in the production of inflammatory mediators and thus exerts excellent antiinflammatory effects in vitro and in vivo Inflammatory diseases such as acute inflammation, intraarticular diseases such as rheumatoid arthritis, skin diseases such as psoriasis, allergic inflammatory diseases such as bronchial asthma, and the like.