THE PREPARATION METHOD OF QUADRIVALENT COMBINATION VACCINE INCLUDING DIPHTHERIA TOXOID, TETANUS TOXOID, ACELLULAR PERTUSSIS ANTIGENS AND HEPATITIS B SURFACE ANTIGEN

摘要

The present invention is a tetravalent mixed vaccine including diphtheria, tetanus toxoid and purified pertussis and hepatitis B surface antigen, and a method for preparing the same, and finely controlling the content of tetanus toxoid and the amount of aluminum hydroxide gel adsorbent. It is characterized in that the immunogenicity of hepatitis surface antigens is stably maintained and at the same time reduced toxicity.;The mixed vaccine according to the present invention has an effective antibody formation rate of 90% or more in the case of hepatitis B surface antigen immunogenicity, and a mouse weight loss toxicity of 10 BWDU / mL or less while maintaining the geometric average antibody value of 270 mIU / mL or more. I can keep it.