Solid oral compositions comprising Trimegestone, an estradiol, and a buffer at pH 2 to 5.5, are contraceptives and useful for prevention of menopausal symptoms or osteoporosis

摘要

The invention concerns a pharmaceutical composition comprises trimegestone optionally associated with an oestrogen, characterized in that it comprises a buffer solution whereof the pH, when it is introduced in the composition, ranging essentially between 2 and 5.5. The invention also concerns the methods for making such a composition and the primary package containing them.