process for the production of a nor seco compounds with steran skeleton

摘要

The invention relates to a new process for the synthesis of 17beta-hydroxy-17alpha-methyl-1,3-seco-2-nor-5alpha-androstane-3-acid derivatives of formula (I)wherein the meaning of Z is carboxyl or formyl group andto the new secoindoxylidene carboxylic acid derivatives of formula (II)wherein R1 and R2 independently are C1-C4 alkyl or alkoxy group, hydrogen or halogen atom-which are intermediates for preparing the compounds of formula (I).The 17beta-hydroxy-17alpha-methyl-1,3-seco-2-nor-5alpha-androstane-3-acid derivatives of formula (I) are intermediates in the synthesis of oxandrolon (17beta-hydroxy-17alpha-methyl-2-oxa-5alpha-androstane-3-one), which is used as anabolic in therapy.