In vitro diagnosis of cancer, particularly breast and ovarian cancer, or susceptibility, comprises detecting alterations in the acetyl coenzyme A-carboxylase alpha gene or protein expression

摘要

In vitro diagnosis of cancer (or of an increased risk of developing it) comprises detecting an alteration in the either the sequence of the acetyl coenzyme A-carboxylase alpha (ACCa) gene or in expression of ACCa protein, relative to a control population. Independent claims are also included for the following: (1) Isolated nucleic acid (Ia) comprising a partial sequence of the ACCa gene (or derived cDNA) which includes one of the polymorphisms 1866 + 67T to C or 610-16T to C; and (2) Isolated nucleic acid (Ib) comprising a partial sequence of the ACCa gene (or derived cDNA) which includes one of the mutations 4213C to G or 6812C to T.