Method of screening for genes or agents affecting the response of the Drosophila heart to hypoxia or anoxia

摘要

The present invention provides a novel method of screening for a gene or an agent affecting cardiac function after or during hypoxia or anoxia, including the steps of: providing an adult Drosophila in conditions able to induce hypoxia or anoxia, imaging the heart of the Drosophila, measuring the movements of the heart in the image, analyzing the measurements of the movements, and identifying a gene affecting the cardiac function of the Drosophila or identifying the effect of the agent on the cardiac function. The method may include administering an agent before, during or after hypoxia.