A Beta form of Prion Protein, a preparation method thereof, a composition containing the same, use for the manufacture of a composition, a monoclonal antibody, a method for their preparation, a hybridoma Cell, a liaison officer from the beta form, a method for their Preparation

摘要

Se refiere a una forma beta de una prote na de pri n que tiene ms estructura de l mina beta que de h lice alfa puede existir como un mon mero y puede retener la solubilidad en soluci n acuosa en ausencia de un desnaturalizante un m todo para a binding agent of the beta form, a method for its preparation, use thereof for the preparation of a composition for the prevention, treatment and diagnosis of a disease caused by prions, methods for detecting in a biological sample, and a diagnostic kit. It also refers to the use of the beta form in medicine, especially to cultivate antibodies useful in the treatment and / or diagnosis of diseases caused by prions. It also refers to a method for the classification of compounds that are capable of inhibiting and / or reversing the conversion of the natural alpha form of a prion protein to a beta form,And the medical use of the compounds that have been identified.