Intermediate 4 - substituted Pyridine Compound, Process for preparing a Compound, Process for Preparation of substituted Pyridine Intermediate 4 - alquilamino and Procedure for preparing a benzamide Compound

摘要

It provides a favorable 4 - substituted Pyridine Compound of formula (2): for an improved procedure for use in preparation of benzamide Derivatives of formula (1) that are known to be inhibitors of Thrombin (1 (where R1 and R2 independently represent a Group (3) or R1 and R2 ju Form a group or many heterocicloalquilo heterocicloalquenilo C3 - 7Which may optionally be substituted with alkyl group C1 - 6, c1-4 alkoxy, halogen, carboxylic acid or an ester of a carboxylic acid c1-4; R3 represents Hydrogen, halogen, alkyl or alkoxy C1 C1 - 3 - 2; R4, R5 and R6 independently represent Hydrogen or Halogen; R7 represents Hydr u00f3geno C1 - alkyl or cycloalkyl R8 represents Hydrogen; 6, 8 cicloalquenilo C3, C3 - 7Heterocicloalquilo C3 C3 - 7 - 7, heterocicloalquenilo, aryl, heteroaryl groups which are optionally substituted with one or more selected groups of halogen, Hydroxy, alkoxy alkyl C1 CN - 6, 6 - aciloxi C1, C1 - 6, nr9r10, nhcor11, nhso2r12, cor13, co2r14, conr15r16, and so2nhr17, X represents A Link, a C1 - 6 alkyl Chain, or a Chain of alquenilo C3 - 6With optionally one or two Atoms of Nitrogen, Oxygen or Sulfur can be contained in each chain and the chains are optionally substituted with one or more selected groups of halogen, Hydroxy, NS, 6 - alkoxy alkyl C1, C1 - 6 - 6, aciloxi C1, nr9r10, nhcor11, nhso2r12, cor13, CO2R 14, conr15r16 and so2nhr17; R9 - R17 represent Hydrogen, alkyl C1 - 6Or R9 and R10 or R15 and R16 form a ring heterocicloalquilo C3 - 7, or R12 additionally can represent trifluoromethyl