Compositions containing a compound imidazotriazinona and at least a local anesthetic for nasal Administration, the use of said composition for the preparation of a Medicament for the treatment of male erectile dysfunction, an Applicator and a Powder Spray nasal insufflator

摘要

The ingredients include not less than one inhibitor of zinc phosphate and not less than one local anesthetic, provided that the local anesthetic is not ethanol, For a PDE GMPC inhibitor of formula (1), R1 represents hydrogen or a linear chain tar or a branch of up to four carbon atoms, R2 represents a linear chain tar of up to four carbon atoms, R3 and R4 are equal or different, representing a linear tar or branched chain of up to five carbon atoms,which is optionally substituted up to twice equally or differently with hydroxyl or methoxy or R3 and R4 together with the nitrogen atom form a piperidinyl, morpholinyl, thiomorpholinyl ring, or a radical of formula (1) in which R7 means hydrogen , formyl, acyl or straight or branched chain alkoxycarbonyl with up to 6 carbon atoms respectively, or means straight or branched chain alkyl of up to 6 carbon atoms that is optionally substituted one to two times equally or differently with hydroxyl, carboxyl, straight or branched chain alkoxy or alkoxycarbonyl of up to 6 carbon atoms respectively,O refers to C3-8 cyclopentanediol, a heterocycle composed of R3 and R4 above, together with nitrogen atoms, which can be selectively replaced by 1 to 2 times in the same or different ways, or by double moaning, using hydroxyl, thyroid, carbohydrate, acid or carbonate, or derivatives of up to 6 carbon atoms. The heterocycle composed of R3 and R4 and nitrogen atoms can be replaced by linear chain tar or branches of up to 6 carbon atoms, which are replaced by hydroxyl or carbohydrate in one or two same or different ways,And / or a heterocycle consisting of R3 and R4 as described above, together with nitrogen atoms, optionally substituted by pyridine or pyridine in combination with N, R5 and R6, which are equal or different and represent hydrogen, linear chain tar or branches of up to six carbon atoms or hydroxyl groups, O oxygen containing groups and their salts, isomers and / or hydrates representing linear or discrete chains of up to six carbon atoms; use of this component to prepare drugs, nasal sprayers and powder sprays for the treatment of erectile dysfunction in men.