One or more isolated polynucleotide sequences, vector, host cell, composition, arrangement, methods for diagnosing mild, moderate, severe and severe osteoarthritis in a patient, to identify an agent that increases or decreases the expression of a polynucleotide sequence, to prepare a chondrocyte cdna collection, and to manufacture a disposition, and set

摘要

"ONE OR MORE SEQUENCES OF POLLUCLEOTIDE ISOLATED, VECTOR, HOST CELL, COMPOSITION, ARRANGEMENT, METHODS FOR DIAGNOSIS BRAND, MODERATE, ACCENTED AND SERIOUS DIAGNOSIS FOR A DIFFERENTLY EXPRESSED PATIENTS TO PREPARE A CONDROCY CDNA COLLECTION, AND TO MAKE A ARRANGEMENT, AND ASSEMBLY ". The invention provides one or more polynucleotide sequences that are expressed in chondrocytes from any of the following developmental and disease stages: fetal, normal, mild, osteoarthritic, moderate, severe and osteoarthritic osteoarthritic. The invention also relates to arrangements and compositions comprising any combination of these polynucleotide sequences. The invention also provides methods of using the provisions of the invention to diagnose osteoarthritis. The invention also provides methods of identifying therapeutic agents that alter the expression level of the polynucleotides of the invention or alter the anabolic level of a chondrocyte.