Protein, recombinant polypeptide, nucleic acid sequence and vector, cultured cell, nucleotide primer, purified antibody, immunogenic, vaccine and pharmaceutical compositions, screening process for molecules likely to inhibit growth of major leishmania, use of an acid probe nucleic acid, one or more inhibitors of protein disulfide isomerases and bacitracin or zinc bacitracin, in vitro diagnostic method of a parasitic infection responsible for leishmaniasis and diagnostic kit for carrying out the method

摘要

"PROTEIN, RECOMBINANT POLYPEPTIDE, NUCLEIC ACID SEQUENCE AND VECTOR, CELL IN CULTURE, NUCLEOTHYTIC INITIATOR, IMMUNOGENIC COMPOSITIONS, VACCIN AND PHARMACISTIC PROCESSES LEISE MUSIC DECEPTIAN DECESSES NUCLEIC ACID, ONE OR SEVERAL INHIBITORS OF PROTEIN ISOMERASE DISEASES AND BACITRACINE OR ZINC BACITRACINE, IN VITRO DIAGNOSTIC METHOD OF AN INFECTION BY A PARASITE RESPONSIBLE FOR KITALISM AND THE REISHING DIAGNOSIS. The invention lies in the domain of the fight against leishmaniasis. It results from the isolation, from wild isolates of Leishmania major, of a gene encoding a protein, called LmPDI, which has two regions identical to the sequence (Cys-Gly-His-Cys) of the potential active site of protein disulfide isomerases (PDI). ). This LmPDI protein is predominantly expressed in the most virulent isolates of the parasite. On the one hand, it constitutes a new therapeutic label for the elaboration of anti-leishmaniasis medicines and, on the other hand, a novel element that can be used in the composition of immunogen and possibly vaccination preparations, intended to protect a host, human or animal. , against Leishmania.