(Pyrido / thieno) - f -oxazepin-5-one derivative, pharmaceutical composition, use of a (pyrido / thieno) - f -oxazepin-5-one derivative, and method of treating a disease neurological disorder or a psychiatric disorder

摘要

"(FIRY / TIENO) DERIVATIVE - [F] -OXAZEPIN-5-ONA, PHARMACEUTICAL COMPOSITION, USE OF A (FIRY / TIENO) - [F] -OXAZEPIN-5-ONA, AND, TREATMENT METHOD OF A NEUROLOGICAL DISEASE OR PSYCHIATRIC DISORDER ". The present invention relates to (pyrido / thieno) [f] -oxazepin-5-one derivatives having General Formula I wherein R 1, R 2 and R 3 are independently H or C (C) alkyl. ~ 1-4 ~); Ar represents a fused thiophene or pyridine ring optionally substituted by one or more substituents selected from C1-4 alkyl, C1-4 alkyloxy, C1-4 alkyloxy and C1-4 alkyl ~ 1-4 ~), CF ~ 3 ~, halogen, nitro, cyano, NR ^ 4 ^ R ^ 5 ^, NR ^ 4 ^ COR ^ 6 ^ and CONR ^ 4 ^ R ^ 5 ^, R ^ 4 ^ e R 5 are independently H or C 1-4 alkyl; or R 4 and R 5 form together with the nitrogen atom to which they are attached a 5 or 6 membered saturated heterocyclic ring, optionally containing another heteroatom selected from O, S or NR 6 6; R6 is C (1-4) alkyl; A represents the residue of a 4- to 7-membered saturated heterocyclic ring, optionally containing an oxygen atom, the ring being optionally substituted by 1 to 3 substituents selected from (1-4C) alkyl, (1-4C) alkyloxy ), hydroxy, halogen and oxo; or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, and the use of these (pyrido / thieno) [f] -oxazepin-5-one derivatives in the treatment of neurological disorders and psychiatric disorders that are responsive to the intensification of mediated synaptic responses. AMPA receptors in the central nervous system.