Single chain hybrid plasminogen activator, DNA sequence encoding therefore, hybrid vector containing the DNA sequence, eukaryotic host cell transformed with the hybrid vector, method of producing the single chain hybrid plasminogen activator, ......

摘要

Novel single-chain hybrid plasminogen activators having an amino acid sequence composed of at least two subsequences corresponding in amino acid identity and number to subsequences of human t-PA and of human u-PA, and mutants thereof in which at least one of the N-glycosylation sites is modified such that glycosylation cannot take place at these sites exhibit valuable pharmacological properties. The hybrid plasminogen activators are produced by recombinant DNA technology.