Vector encoding self-accumulating, defective, non-self-propagating virus particles

摘要

Plasmid vectors for insertion of HIV or SIV DNA sequences into a pox virus by in-vivo recombination, the plasmid vector comprising: a) a prokaryotic origin of replication b) a gene encoding a marker c) two gene sequences from single species of HIV or SIV d) pox virus sequences flanking c).