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NITRO-BENZAMIDES USEFUL AS ANTI-ARRHYTHMIC AGENTS AND PHARMACEUTICALS CONTG. THEM
NITRO-BENZAMIDES USEFUL AS ANTI-ARRHYTHMIC AGENTS AND PHARMACEUTICALS CONTG. THEM
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机译:硝基苯甲酰胺常用作抗心律失常剂和药物。他们
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摘要
The present invention relates to novel compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates thereof, to pharmaceutical compositions containing them, and to their use as pharmaceutical active ingredients. In the formula (I), Ar is optionally substituted with (C 1 -C 6) -alkyl, hydroxy or (C 1 -C 6) -alkoxy; It is a straight-chain alkylene group containing from 1 to 4 carbon atoms, each carbon atom being optionally substituted singly or twice by a alkyl group of 1 to 6 carbon atoms; R 1 is hydrogen or C 1-6 alkyl; R2 is nitro; R3 and R4 are hydrogen; X is -CO-NH-; and Z is -CH2CH2-CH2-. The compounds have antiarrhythmic activity. ŕ
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