An improved process for conversion of trans-n-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine to its cis-n-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine (an intermediate of sertraline hydrochloride )

摘要

The present invention relates to an improved process for converting trans isomer of N methyl-4-(3,4-dich!orophenyl)-l ,2,3,4-tetrahydro-l-naphthalencamine to corresponding cis isomeric product. The cis isomer serves as valuable intermediate in the production of Cis (lS)(4S)-N-methyl-4-(3,4-dichlorophenyl)-l,2,3.4-tetrahydro-l-naphthaleneamine, which is a potent anti-depressant agent. The improved method of preparation is safe, cost effective and industrially scalable.