New bicyclic amino-pyrazinone derivatives and their isomers and salts, useful as thrombin inhibitors for treating cardiovascular diseases such as angina pectoris, thrombosis, atherosclerosis, arteritis and venous disease

摘要

A compound selected from those of formula (I):wherein:R1 represents hydrogen, optionally substituted alkyl, cycloalkyl or heterocycloalkyl or a group of formula (G):wherein A1 represents single, -CH2-, -CH2-CH2- or -N(CH3)- or oxygen or sulphur, and X1 and X2, which may be identical or different, each represent carbon or nitrogen,R represents hydrogen or linear or branched (C1-C6)alkyl, represents a saturated ring having from 4 to 7 ring members,n represents integer wherein 1=n=6,Ar represents aryl or heteroaryl,its isomers, N-oxydes and pharmaceutically-acceptable acid or base addition salts thereof.