IMIDAZOLE, THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT AND/OR PREVENTION OF POLLAKIURIA OR URINARY INCONTINENCE

摘要

Title: IMIDAZOLE, THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT AND/OR PREVENTION OF POLLAKIURIA OR URINARY INCONTINENCE[err] (I)Abstract: A large conductance calcium-activated K channel opener comprising as an active ingredient a nitrogen-containing 5-mem-bered heterocyclic compound represented by the following formula (I): wherein X represents N-R[err], O or S, R[err] and R[err] each independently represent hydrogen, halogen carboxyl, amino, lower alkyl, lower alkoxycarbonyl, lower alkenyl, cyclo-lower alkyl, carbamoyl, aryl, heterocyclic or heterocyclic-substituted carbonyl group, R[err] representsaryl, heterocyclic or lower alkyl group, and R[err] represents hydrogen or lower alkyl group, or a pharmaceutically acceptable salt thereof and its use for the preparation of a medicament for the phophylaxis and/or treatment of pollakiuria or urinary incontinence.