INCREASING THE HDL LEVEL AND THE HDL/LDL RATIO IN HUMAN SERUM BY BALANCING SATURATED AND POLYUNSATURATED DIETARY FATTY ACIDS

摘要

A method of increasing the HDL concentration and theHDL/LDL concentration ratio in human serum by providing abalance between a sufficient and required proportion ofcholesterol-free saturated fatty acids in the dailydietary fat of the human and a sufficient and required,but not excessive, proportion of polyunsaturated fattyacids comprising linoleic acid in dietary fat, while theremaining proportion of fatty acids and energy from thedietary fat is provided by monounsaturated fatty acidscomprising oleic acid. The saturated fatty acids mustconstitute between 20% and 40% by weight of the dailydietary fat based upon dietary fat accounting for 30% ofthe total dietary energy consumption, and linoleic acidmust constitute between 15% and 40% by weight of dietaryfat. In this way, the required proportional intake ofpolyunsaturated fatty acids enhances the formation of HDLfrom VLDL and/or decreases the clearance of HDL, while anexcessive proportional intake of polyunsaturated fattyacids and monounsaturated fatty acids is avoided to assurea sufficient dietary availability of saturated fatty acidswhich are required for sufficient VLDL synthesis and HDLproduction.