EGF-LIKE FACTOR FROM CHROMAFFIN GRANULES AND GLIA CELL-DERIVED NEUROTROPHIC FACTOR WITH SURVIVAL-PROMOTING ACTIVITY ON DAERGIC NEURONS

摘要

The present invention relates to chromaffin granule-derived EGF-like proteinsthat are involved in promoting survival of DAergicneurons, to nucleotide sequences encoding said proteins or a functionallyactive derivative or part thereof, and to processes for theirpreparation. The present invention relates further on to glia cell-derivedneurotrophic factors that are capable of promoting survival ofDAergic neurons, to nucleotide sequences encoding said factors or afunctionally active derivative or part thereof, and to a process for theirpreparation.