NOVEL THERAPEUTICAL USE OF AGONIST LIGANDS SPECIFIC TO LYSOPHOSPHATIDIC ACID RECEPTOR

摘要

The present invention relates to a novel therapeutical use of agonist ligands specific to lysophosphatidic acid receptors. More particularly, the present invention relates to methods for treating diseases or disorders associated with excessive neutrophil accumulation in a subject, comprising administering LPA (1-acyl or 2-acyl lysophosphatidic acid) or the derivatives thereof to the subject. The agonist ligands for lysophosphatidic acid receptor according to the present invention and pharmaceutical- or therapeutical composition comprising said ligands can be used 10 effectively in treatment of diseases or disorders associated with neutrophil accumulation and hyperactivity, specifically inflammatory diseases and diseases associated with ischemia-reperfusion injury.