GENE EXPRESSION PROFILING OF ENDOTHELIUM IN ALZHEIMER'S DISEASE

摘要

Changes in the gene expression profile of vascular endothelium are associated with or may be a cause for Alzheimer's disease. This observation can be used to diagnose the disease in symptomatic or asymptomatic individuals, to identify those at risk for disease or already affected thereby, to determine the stage of disease or the disease's progression, to intervene earlier in or alter the natural history of the disease, to provide targets for therapeutic or prophylactic treatments, to screen drugs or otherwise compare medical regimens, to determine the effectiveness of a drug or medical regimen, or any combination thereof. Gene expression may be profiled at the level of transcription (e.g., products like hnRNA, mRNA, and other RNA) and/or translation (e.g., products like nascent polypeptide, mature protein, and other processed or modified proteins).