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SCHIZOPHRENIA-LIKE MENTAL DISEASE MODEL ANIMAL, METHOD OF CONSTRUCTING THE SAME AND USE THEREOF
SCHIZOPHRENIA-LIKE MENTAL DISEASE MODEL ANIMAL, METHOD OF CONSTRUCTING THE SAME AND USE THEREOF
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机译:精神分裂症样精神病模型动物,其构造方法及其用途
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摘要
The present invention relates to a schizophrenia-like cognitive dysfunction animal model; a method of preparing the same; and a method of evaluating schizophrenia-like cognitive dysfunction by using said model. Specifically, the present invention relates to the preparation of a mammal showing continuous cognitive abnormality after sexual maturation, by allowing an excessive presence of interleukin 1 or an analog thereof and/or an intracellular signal transducer induced by interleukin 1 or an analog thereof in the body of young animal during the stages of brain function development; and a method of evaluating cognitive dysfunction by ethologically measuring the cognitive abnormality in the animal.
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