USE OF BINDING DOMAINS OF PRESENILINS FOR DRUG SCREENING

摘要

The present invention relates to the identification of the molecular binding domains between presenilins and its substrates such as amyloid precursor protein and telencephalin. These binding domains can be efficiently used in drug screening assays to screen for compounds capable of modulating the interaction between presenilins and type I transmembrane proteins. In particular, the binding domains are: (a) the first transmembrane domain of presenilin, (b) the last 8 carboxyterminal amino acids of presenilin and (c) the transmembrane domain of said type I transmembrane protein. The invention further relates to compounds capable of modulating said interaction.