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49-57 49-57 Conjugate of biodegradable aliphatic polyester with Tat49-57 peptide or peptide chain containing Tat49-57 peptide and nanoparticle manufactured using the same
49-57 49-57 Conjugate of biodegradable aliphatic polyester with Tat49-57 peptide or peptide chain containing Tat49-57 peptide and nanoparticle manufactured using the same
PURPOSE: A conjugate of biodegradable aliphatic polyester with Tat49-57 peptide or Tat49-57 peptide-containing peptide chain, and a nanoparticle manufactured using the same conjugate are provided. The cell penetration of the nanoparticle is increased by exposing Tat peptide on the surface of the nanoparticle. CONSTITUTION: A conjugate of biodegradable aliphatic polyester with Tat49-57 peptide having the nucleotide sequence of SEQ ID NO: 1 or Tat49-57 peptide-containing peptide chain is provided, wherein the biodegradable aliphatic polyester is one or more components selected from copolymers manufactured from poly(D-lactic acid), poly(L-lactic acid), poly(D,L-lactic acid), poly(D-lactic acid-co-glycolic acid), poly(L-lactic acid-co-glycolic acid), poly(D,L-lactic acid-co-glycolic acid), poly(caprolactone), poly(valerolactone), poly(hydroxy butyrate), poly(hydroxy valerate), poly(1,4-dioxan-2-one), poly(ortho ester) and monomers thereof. A nanoparticle manufactured using the conjugate of biodegradable aliphatic polyester with Tat49-57 peptide or Tat49-57 peptide-containing peptide chain has average particle size of 1,000 nm or less.
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机译:目的:提供可生物降解的脂族聚酯与含有Tat49-57肽或含Tat49-57肽的肽链的缀合物,以及使用该缀合物制造的纳米颗粒。通过将Tat肽暴露在纳米颗粒的表面上来增加纳米颗粒的细胞渗透。组成:提供了可生物降解的脂肪族聚酯与具有核苷酸序列SEQ ID NO:1的Tat49-57肽或含有Tat49-57的肽链的缀合物,其中所述可生物降解的脂肪族聚酯是一种或多种选自以下的组分:聚(D-乳酸),聚(L-乳酸),聚(D,L-乳酸),聚(D-乳酸-乙醇酸),聚(L-乳酸-乙醇酸) ),聚(D,L-乳酸-乙醇酸共聚物),聚(己内酯),聚(戊内酯),聚(羟基丁酸酯),聚(羟基戊酸酯),聚(1,4-二恶烷-2-酮) ),聚(原酸酯)及其单体。使用可生物降解的脂族聚酯与含有Tat49-57肽或含Tat49-57肽的肽链的缀合物制造的纳米颗粒具有1,000nm或更小的平均粒径。
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