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EXPRESSION SYSTEM OF HUMAN SERUM ALBUMIN-TIMP-2 FUSION PROTEIN AND RECOMBINANT HUMAN SERUM ALBUMIN- TIMP-2 PROTEIN
EXPRESSION SYSTEM OF HUMAN SERUM ALBUMIN-TIMP-2 FUSION PROTEIN AND RECOMBINANT HUMAN SERUM ALBUMIN- TIMP-2 PROTEIN
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机译:人血清白蛋白-TIMP-2融合蛋白和重组人血清白蛋白-TIMP-2蛋白的表达系统
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摘要
The present invention provides a human serum albumin-TIMP2 fusion protein having the amino acid sequence set forth in SEQ ID NO. 10, a polynucleotide encoding the same and a vector comprising the polynucleotide, a host cell transformed with the vector, a method for producing the human serum albumin-TIMP2 fusion protein and a pharmaceutical composition comprising the human serum albumin-TIMP2 fusion protein. The human serum albumin-TIMP2 fusion protein is stable and retains the activity of TIMP2, thus it can be used as a pharmaceutical composition to treat diseases related to angiogenesis and/or metastasis of cancer cells.
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机译:本发明提供了具有SEQ ID NO.1所示氨基酸序列的人血清白蛋白-TIMP2融合蛋白。参照图10,编码该多核苷酸的多核苷酸和包含该多核苷酸的载体,用该载体转化的宿主细胞,生产人血清白蛋白-TIMP2融合蛋白的方法和包含人血清白蛋白-TIMP2融合蛋白的药物组合物。人血清白蛋白-TIMP2融合蛋白是稳定的并且保留TIMP2的活性,因此其可以用作治疗与癌细胞的血管生成和/或转移有关的疾病的药物组合物。
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