METHOD FOR PREDICTING THE RESULT OF PREGNANCY IN WOMEN OUT OF RISK GROUP ON INTRAUTERINE FETAL INFECTIONING

摘要

FIELD: medicine, obstetrics, gynecology.;SUBSTANCE: in the second trimester of gestation one should evaluate the complex of clinico-laboratory maternal/fetal values. One should take into account: the flow of gestation complicated by development of average- and severe-degree gestosis (DC = +6.3), uncomplicated by the development of gestosis (DC = -7.5); the availability of US-markers of prenatal fetal pathology (DC = +2.9), the frequency of vaginal smears of 3-6 degree (DC = +1.8), the quantity of segmented neutrophils in maternal blood ≥70% (DC = +7.9), ≤65% (DC = -2.9), leucocytosis in fetal blood ≥4.5% * 10⁹/l (DC = +6.8), ≤3.0 * 10⁹/l (DC = -6.9); absolute lymphocytosis in fetal blood ≥3.0 * 10⁹/l (DC = +4.1); absolute content of CD3⁺ T-cells ≥1.9 * 10⁹/l (DC = +2.5), ≥0.4 g/l (DC = -5.5); relative quantity of HLA-DR⁺ monocytes and HLA-DR⁺ lymphocytes in fetal blood, correspondingly ≥88 and 30% (DC = -6.2) and (DC = -4.0). At total value of positive diagnostic coefficients (Σ DC = +13 and higher) one should predict the development of unfavorable perinatal result, and at total value of negative diagnostic coefficients (Σ DC = -17 and lower) - favorable result of pregnancy. The method enables to optimize the tactics for treating pregnant women.;EFFECT: higher efficiency and accuracy of prediction.;3 ex