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New 1-chloro-5-methylene-7-hydroxy-9,9-dimethyl-spiro(5.5)undec-2-enes useful as antibiotics for treating infectious diseases and for preventing transmission of staphylococcal infections in cattle
New 1-chloro-5-methylene-7-hydroxy-9,9-dimethyl-spiro(5.5)undec-2-enes useful as antibiotics for treating infectious diseases and for preventing transmission of staphylococcal infections in cattle
1-Chloro-5-methylene-7-hydroxy-9,9-dimethyl-spiro[5.5]undec-2-enes (I) are new. 1-Chloro-5-methylene-7-hydroxy-9,9-dimethyl-spiro[5.5]undec-2-enes of formula (I) are new. [Image] R1H, acetyl, benzoyl, Me, Et or glycosyl; R2H, halo or NH2; R3H or halo; R4H, 1-10C alkyl, halo or NH2; and R5H, alkyl or C-glycoside. An independent claim is also included for a (I)-containing extract of Laurencia seaweed. ACTIVITY : Antibiotic. The zone of inhibition produced by placing a 6 mm sensi-disc coated with 1-chloro-5-methylene-7-hydroxy-9,9-dimethyl-spiro[5.5]undec-2-ene on a methicillin-resistant Staphylococcus aureus culture and incubating at 37 [deg]C for 18-20 hours was 8.3 mm. MECHANISM OF ACTION : None given.
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机译:1-氯-5-亚甲基-7-羟基-9,9-二甲基-螺[5.5]十一碳-2-烯(I)是新的。式(I)的1-氯-5-亚甲基-7-羟基-9,9-二甲基-螺[5.5]十一碳-2-烯是新的。 [图像] R1> H,乙酰基,苯甲酰基,Me,Et或糖基; R 2> H,卤素或NH 2; R3> H或卤素; R4> H,1-10C烷基,卤素或NH2; R 5> H,烷基或C-糖苷。还包括劳伦西亚海藻的含(I)提取物的独立权利要求。活动:抗生素。通过将涂有1-氯-5-亚甲基-7-羟基-9,9-二甲基-螺[5.5]十一碳-2-烯的6毫米感觉圆盘置于耐甲氧西林的金黄色葡萄球菌培养物上而产生的抑制区在37℃下孵育18-20小时为8.3mm。作用机理:未给出。
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